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IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells

While the role of hypoxia and the induction of the hypoxia inducible factors (HIFs) and the unfolded protein response (UPR) pathways in the cancer microenvironment are well characterized, their roles and relationship in normal human endothelium are less clear. Here, we examined the effects of IRE1 o...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Moszyńska, Adrianna, Collawn, James F., Bartoszewski, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355874/
https://ncbi.nlm.nih.gov/pubmed/32545307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10060895
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