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IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells

While the role of hypoxia and the induction of the hypoxia inducible factors (HIFs) and the unfolded protein response (UPR) pathways in the cancer microenvironment are well characterized, their roles and relationship in normal human endothelium are less clear. Here, we examined the effects of IRE1 o...

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Publicat a:Biomolecules
Autors principals: Moszyńska, Adrianna, Collawn, James F., Bartoszewski, Rafal
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7355874/
https://ncbi.nlm.nih.gov/pubmed/32545307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10060895
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