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Stability of New Carbapenem DA-1131 to Renal Dipeptidase (Dehydropeptidase I)

The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme's preference for substrates. Our results showed a decreasing order of imipenem (6.24), meropenem (2.41), and DA-1131 (1.39). The bioc...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Park, Sung Wook, We, Jeoung Soon, Kim, Gye Won, Choi, Seong Hak, Park, Haeng Soon
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127065/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796382/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.575-577.2002
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