Process and Metabolic Strategies for Improved Production of Escherichia coli-Derived 6-Deoxyerythronolide B

Recently, the feasibility of using Escherichia coli for the heterologous biosynthesis of complex polyketides has been demonstrated. In this report, the development of a robust high-cell-density fed-batch procedure for the efficient production of complex polyketides is described. The effects of vario...

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Veröffentlicht in:	Appl Environ Microbiol
Hauptverfasser:	Pfeifer, Blaine, Hu, Zhihao, Licari, Peter, Khosla, Chaitan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Physiology and Biotechnology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12089005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.7.3287-3292.2002
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