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Process and Metabolic Strategies for Improved Production of Escherichia coli-Derived 6-Deoxyerythronolide B

Recently, the feasibility of using Escherichia coli for the heterologous biosynthesis of complex polyketides has been demonstrated. In this report, the development of a robust high-cell-density fed-batch procedure for the efficient production of complex polyketides is described. The effects of vario...

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Autors principals: Pfeifer, Blaine, Hu, Zhihao, Licari, Peter, Khosla, Chaitan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126764/
https://ncbi.nlm.nih.gov/pubmed/12089005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.68.7.3287-3292.2002
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