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Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli
Ansamycins such as rifamycin, ansamitocin, and geldanamycin are an important class of polyketide natural products. Their biosynthetic pathways are especially complex because they involve the formation of 3-amino-5-hydroxybenzoic acid (AHBA) followed by backbone assembly by a hybrid nonribosomal pept...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187841/ https://ncbi.nlm.nih.gov/pubmed/12888623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1632167100 |
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