Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli

Ansamycins such as rifamycin, ansamitocin, and geldanamycin are an important class of polyketide natural products. Their biosynthetic pathways are especially complex because they involve the formation of 3-amino-5-hydroxybenzoic acid (AHBA) followed by backbone assembly by a hybrid nonribosomal pept...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Watanabe, Kenji, Rude, Mathew A., Walsh, Christopher T., Khosla, Chaitan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2003
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187841/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1632167100
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