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Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host

The medicinal value associated with complex polyketide and nonribosomal peptide natural products has prompted biosynthetic schemes dependent upon heterologous microbial hosts. Here we report the successful biosynthesis of yersiniabactin (Ybt), a model polyketide-nonribosomal peptide hybrid natural p...

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Detalhes bibliográficos
Main Authors: Pfeifer, Blaine A., Wang, Clay C. C., Walsh, Christopher T., Khosla, Chaitan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC262314/
https://ncbi.nlm.nih.gov/pubmed/14602630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.11.6698-6702.2003
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