Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host

The medicinal value associated with complex polyketide and nonribosomal peptide natural products has prompted biosynthetic schemes dependent upon heterologous microbial hosts. Here we report the successful biosynthesis of yersiniabactin (Ybt), a model polyketide-nonribosomal peptide hybrid natural p...

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Autores principales: Pfeifer, Blaine A., Wang, Clay C. C., Walsh, Christopher T., Khosla, Chaitan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Physiology and Biotechnology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC262314/
https://ncbi.nlm.nih.gov/pubmed/14602630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.11.6698-6702.2003
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