Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host

The medicinal value associated with complex polyketide and nonribosomal peptide natural products has prompted biosynthetic schemes dependent upon heterologous microbial hosts. Here we report the successful biosynthesis of yersiniabactin (Ybt), a model polyketide-nonribosomal peptide hybrid natural p...

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Autors principals: Pfeifer, Blaine A., Wang, Clay C. C., Walsh, Christopher T., Khosla, Chaitan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Physiology and Biotechnology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC262314/
https://ncbi.nlm.nih.gov/pubmed/14602630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.11.6698-6702.2003
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