Selective Escape from CD8(+) T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution

The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear. To address this issue we assessed the relationship between genome-wide viral evolution...

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Hlavní autoři: Allen, Todd M., Altfeld, Marcus, Geer, Shaun C., Kalife, Elizabeth T., Moore, Corey, O'Sullivan, Kristin M., DeSouza, Ivna, Feeney, Margaret E., Eldridge, Robert L., Maier, Erica L., Kaufmann, Daniel E., Lahaie, Matthew P., Reyor, Laura, Tanzi, Giancarlo, Johnston, Mary N., Brander, Christian, Draenert, Rika, Rockstroh, Jurgen K., Jessen, Heiko, Rosenberg, Eric S., Mallal, Simon A., Walker, Bruce D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262562/
https://ncbi.nlm.nih.gov/pubmed/16227247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13239-13249.2005
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