De Novo Generation of Escape Variant-Specific CD8(+) T-Cell Responses following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection

Human immunodeficiency virus type 1 (HIV-1) evades CD8(+) T-cell responses through mutations within targeted epitopes, but little is known regarding its ability to generate de novo CD8(+) T-cell responses to such mutants. Here we examined gamma interferon-positive, HIV-1-specific CD8(+) T-cell respo...

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Detalhes bibliográficos
Main Authors: Allen, Todd M., Yu, Xu G., Kalife, Elizabeth T., Reyor, Laura L., Lichterfeld, Mathias, John, Mina, Cheng, Michael, Allgaier, Rachel L., Mui, Stanley, Frahm, Nicole, Alter, Galit, Brown, Nancy V., Johnston, Mary N., Rosenberg, Eric S., Mallal, Simon A., Brander, Christian, Walker, Bruce D., Altfeld, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235830/
https://ncbi.nlm.nih.gov/pubmed/16188997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.20.12952-12960.2005
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