The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design

Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons infected with clade B virus. Moreover, HLA-A2-restricted responses are largely absent in the acute phase...

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Main Authors: Altfeld, Marcus, Allen, Todd M., Kalife, Elizabeth T., Frahm, Nicole, Addo, Marylyn M., Mothe, Bianca R., Rathod, Almas, Reyor, Laura L., Harlow, Jason, Yu, Xu G., Perkins, Beth, Robinson, Loren K., Sidney, John, Alter, Galit, Lichterfeld, Mathias, Sette, Alessandro, Rosenberg, Eric S., Goulder, Philip J. R., Brander, Christian, Walker, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069570/
https://ncbi.nlm.nih.gov/pubmed/15795285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.8.5000-5005.2005
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