The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design

Human immunodeficiency virus type 1 (HIV-1) mutates to escape immune selection pressure, but there is little evidence of selection mediated through HLA-A2, the dominant class I allele in persons infected with clade B virus. Moreover, HLA-A2-restricted responses are largely absent in the acute phase...

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Päätekijät: Altfeld, Marcus, Allen, Todd M., Kalife, Elizabeth T., Frahm, Nicole, Addo, Marylyn M., Mothe, Bianca R., Rathod, Almas, Reyor, Laura L., Harlow, Jason, Yu, Xu G., Perkins, Beth, Robinson, Loren K., Sidney, John, Alter, Galit, Lichterfeld, Mathias, Sette, Alessandro, Rosenberg, Eric S., Goulder, Philip J. R., Brander, Christian, Walker, Bruce D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2005
Aiheet:
Pathogenesis and Immunity
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069570/
https://ncbi.nlm.nih.gov/pubmed/15795285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.8.5000-5005.2005
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