Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity

An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles. However, the extent to which escape mutations affect other viral proteins during natural infection is not well understood. We generated recombinan...

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Detalhes bibliográficos
Main Authors: Brockman, Mark A., Chopera, Denis R., Olvera, Alex, Brumme, Chanson J., Sela, Jennifer, Markle, Tristan J., Martin, Eric, Carlson, Jonathan M., Le, Anh Q., McGovern, Rachel, Cheung, Peter K., Kelleher, Anthony D., Jessen, Heiko, Markowitz, Martin, Rosenberg, Eric, Frahm, Nicole, Sanchez, Jorge, Mallal, Simon, John, Mina, Harrigan, P. Richard, Heckerman, David, Brander, Christian, Walker, Bruce D., Brumme, Zabrina L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393549/
https://ncbi.nlm.nih.gov/pubmed/22496233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07133-11
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