Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection

Mutations that allow escape from CD8 T-cell responses are common in HIV-1 and may attenuate pathogenesis by reducing viral fitness. While this has been demonstrated for individual cases, a systematic investigation of the consequence of HLA class I-mediated selection on HIV-1 in vitro replication cap...

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Main Authors: Brockman, Mark A., Brumme, Zabrina L., Brumme, Chanson J., Miura, Toshiyuki, Sela, Jennifer, Rosato, Pamela C., Kadie, Carl M., Carlson, Jonathan M., Markle, Tristan J., Streeck, Hendrik, Kelleher, Anthony D., Markowitz, Martin, Jessen, Heiko, Rosenberg, Eric, Altfeld, Marcus, Harrigan, P. Richard, Heckerman, David, Walker, Bruce D., Allen, Todd M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977869/
https://ncbi.nlm.nih.gov/pubmed/20810731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01086-10
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