Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity

An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles. However, the extent to which escape mutations affect other viral proteins during natural infection is not well understood. We generated recombinan...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Brockman, Mark A., Chopera, Denis R., Olvera, Alex, Brumme, Chanson J., Sela, Jennifer, Markle, Tristan J., Martin, Eric, Carlson, Jonathan M., Le, Anh Q., McGovern, Rachel, Cheung, Peter K., Kelleher, Anthony D., Jessen, Heiko, Markowitz, Martin, Rosenberg, Eric, Frahm, Nicole, Sanchez, Jorge, Mallal, Simon, John, Mina, Harrigan, P. Richard, Heckerman, David, Brander, Christian, Walker, Bruce D., Brumme, Zabrina L.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2012
الموضوعات:
Pathogenesis and Immunity
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393549/
https://ncbi.nlm.nih.gov/pubmed/22496233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07133-11
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