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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate lifespan extension both in budding yeast and worms. Here, we show that SIRT1, the human Sir2 homolog, is recruited to th...

Ausführliche Beschreibung

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Veröffentlicht in:EMBO J
Hauptverfasser: Langley, Emma, Pearson, Mark, Faretta, Mario, Bauer, Uta-Maria, Frye, Roy A., Minucci, Saverio, Pelicci, Pier Giuseppe, Kouzarides, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2002
Schlagworte:
Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126010/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006491/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.10.2383
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