Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate lifespan extension both in budding yeast and worms. Here, we show that SIRT1, the human Sir2 homolog, is recruited to th...

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Main Authors: Langley, Emma, Pearson, Mark, Faretta, Mario, Bauer, Uta-Maria, Frye, Roy A., Minucci, Saverio, Pelicci, Pier Giuseppe, Kouzarides, Tony
格式: Artigo
語言:Inglês
出版: Oxford University Press 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC126010/
https://ncbi.nlm.nih.gov/pubmed/12006491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.10.2383
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