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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate lifespan extension both in budding yeast and worms. Here, we show that SIRT1, the human Sir2 homolog, is recruited to th...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126010/ https://ncbi.nlm.nih.gov/pubmed/12006491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.10.2383 |
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