Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
The yeast Sir2 protein mediates chromatin silencing through an intrinsic NAD-dependent histone deacetylase activity. Sir2 is a conserved protein and was recently shown to regulate lifespan extension both in budding yeast and worms. Here, we show that SIRT1, the human Sir2 homolog, is recruited to th...
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| Publicado no: | EMBO J |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126010/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.10.2383 |
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