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Clue to damage recognition by UvrB: residues in the β-hairpin structure prevent binding to non-damaged DNA

UvrB, the ultimate damage-recognizing component of bacterial nucleotide excision repair, contains a flexible β-hairpin rich in hydrophobic residues. We describe the properties of UvrB mutants in which these residues have been mutated. The results show that Y101 and F108 in the tip of the hairpin are...

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Bibliographic Details
Main Authors: Moolenaar, Geri F., Höglund, Lotta, Goosen, Nora
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125699/
https://ncbi.nlm.nih.gov/pubmed/11689453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.21.6140
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