Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion

Activation of proMMP-2 by MT1-MMP is considered to be a critical event in cancer cell invasion. In the activation step, TIMP-2 bound to MT1-MMP on the cell surface acts as a receptor for proMMP-2. Subsequently, adjacent TIMP-2-free MT1-MMP activates the proMMP-2 in the ternary complex. In this study...

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Main Authors: Itoh, Yoshifumi, Takamura, Akiko, Ito, Noriko, Maru, Yoshiro, Sato, Hiroshi, Suenaga, Naoko, Aoki, Takanori, Seiki, Motoharu
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC125610/
https://ncbi.nlm.nih.gov/pubmed/11532942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4782
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