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The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface

Activation of proMMP-2 and cell surface collagenolysis are important activities of membrane-type 1 matrix metalloproteinase (MT1-MMP) to promote cell migration in tissue, and these activities are regulated by homodimerization of MT1-MMP on the cell surface. In this study, we have identified the tran...

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מידע ביבליוגרפי
Main Authors: Itoh, Yoshifumi, Ito, Noriko, Nagase, Hideaki, Seiki, Motoharu
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442350/
https://ncbi.nlm.nih.gov/pubmed/18337248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709327200
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