Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix

The membrane-anchored collagenase membrane type 1 matrix metalloprotease (MT1-MMP) has been shown to play an essential role during epithelial tubulogenesis in 3D collagen matrices; however, its regulation during tubulogenesis is not understood. Here, we report that degradation of collagen in polariz...

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Bibliographische Detailangaben
Hauptverfasser: Weaver, Sarah A., Wolters, Brit, Ito, Noriko, Woskowicz, Anna M., Kaneko, Kazuyo, Shitomi, Yasuyuki, Seiki, Motoharu, Itoh, Yoshifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117704/
https://ncbi.nlm.nih.gov/pubmed/24463815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.135236
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