RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA

We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double-stranded RNA as a stem–loop caused specific degradation of mRNA followed by loss of protein. After 6 days of RNAi, the parasites’ growth rate declined and the cells...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Wang, Zefeng, Englund, Paul T.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532932/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4674
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