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RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA
We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double-stranded RNA as a stem–loop caused specific degradation of mRNA followed by loss of protein. After 6 days of RNAi, the parasites’ growth rate declined and the cells...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125608/ https://ncbi.nlm.nih.gov/pubmed/11532932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4674 |
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