RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA
We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference (RNAi). Expression of a topoisomerase II double-stranded RNA as a stem–loop caused specific degradation of mRNA followed by loss of protein. After 6 days of RNAi, the parasites’ growth rate declined and the cells...
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| Publicado no: | EMBO J |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125608/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532932/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4674 |
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