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Wobble modification defect in tRNA disturbs codon–anticodon interaction in a mitochondrial disease
We previously showed that in mitochondrial tRNA(Lys) with an A8344G mutation responsible for myoclonus epilepsy associated with ragged-red fibers (MERRF), a subgroup of mitochondrial encephalomyopathic diseases, the normally modified wobble base (a 2-thiouridine derivative) remains unmodified. Since...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125593/ https://ncbi.nlm.nih.gov/pubmed/11532943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4794 |
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