Wobble modification defect in tRNA disturbs codon–anticodon interaction in a mitochondrial disease

We previously showed that in mitochondrial tRNA(Lys) with an A8344G mutation responsible for myoclonus epilepsy associated with ragged-red fibers (MERRF), a subgroup of mitochondrial encephalomyopathic diseases, the normally modified wobble base (a 2-thiouridine derivative) remains unmodified. Since...

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Pubblicato in:	EMBO J
Autori principali:	Yasukawa, Takehiro, Suzuki, Tsutomu, Ishii, Norie, Ohta, Shigeo, Watanabe, Kimitsuna
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11532943/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.17.4794
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