The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
Somatic hypermutation, essential for the affinity maturation of antibodies, is restricted to a small segment of DNA. The upstream boundary is sharp and is probably related to transcription initiation. However, for reasons unknown, the hypermutation domain does not encompass the whole transcription u...
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| Udgivet i: | EMBO J |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11500383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.16.4570 |
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