The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
Somatic hypermutation, essential for the affinity maturation of antibodies, is restricted to a small segment of DNA. The upstream boundary is sharp and is probably related to transcription initiation. However, for reasons unknown, the hypermutation domain does not encompass the whole transcription u...
Uloženo v:
| Vydáno v: | EMBO J |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11500383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.16.4570 |
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