Both DNA strands of antibody genes are hypermutation targets
During the maturation of the immune response, antibody genes are subjected to localized hypermutation. Mutations are not evenly distributed along the V gene; intrinsic hot spots exist that are correlated with primary sequence motifs. Although the mechanism of hypermutation remains unknown, it has be...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8791 |
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