Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells
The variable (V) regions of immunoglobulin heavy and light chains undergo high rates of somatic mutation during the immune response. Although point mutations accumulate throughout the V regions and their immediate flanking sequences, analysis of large numbers of mutations that have arisen in vivo re...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5284 |
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