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The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially
Somatic hypermutation, essential for the affinity maturation of antibodies, is restricted to a small segment of DNA. The upstream boundary is sharp and is probably related to transcription initiation. However, for reasons unknown, the hypermutation domain does not encompass the whole transcription u...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125579/ https://ncbi.nlm.nih.gov/pubmed/11500383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.16.4570 |
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