Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice

During evolution, placental mammals appear to have lost cyclobutane pyrimidine dimer (CPD) photolyase, an enzyme that efficiently removes UV-induced CPDs from DNA in a light-dependent manner. As a consequence, they have to rely solely on the more complex, and for this lesion less efficient, nucleoti...

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Main Authors: Schul, Wouter, Jans, Judith, Rijksen, Yvonne M.A., Klemann, Kyra H.M., Eker, Andre P.M., de Wit, Jan, Nikaido, Osamu, Nakajima, Satoshi, Yasui, Akira, Hoeijmakers, Jan H.J., van der Horst, Gijsbertus T.J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125407/
https://ncbi.nlm.nih.gov/pubmed/12198174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf456
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