Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice

During evolution, placental mammals appear to have lost cyclobutane pyrimidine dimer (CPD) photolyase, an enzyme that efficiently removes UV-induced CPDs from DNA in a light-dependent manner. As a consequence, they have to rely solely on the more complex, and for this lesion less efficient, nucleoti...

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Detalhes bibliográficos
Main Authors: Schul, Wouter, Jans, Judith, Rijksen, Yvonne M.A., Klemann, Kyra H.M., Eker, Andre P.M., de Wit, Jan, Nikaido, Osamu, Nakajima, Satoshi, Yasui, Akira, Hoeijmakers, Jan H.J., van der Horst, Gijsbertus T.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125407/
https://ncbi.nlm.nih.gov/pubmed/12198174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf456
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