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Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization
Hereditary familial amyloidosis of Finnish type (FAF) leading to amyloid in the peripheral and central nervous systems stems from deposition of a 71 residue fragment generated from the D187N/Y variants of plasma gelsolin by two sequential endoproteolytic events. We identify the protease accomplishin...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125307/ https://ncbi.nlm.nih.gov/pubmed/11707399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.22.6277 |
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