Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

Amyloid diseases like Alzheimer's disease and familial amyloidosis of Finnish type (FAF) stem from endoproteolytic cleavage of a precursor protein to generate amyloidogenic peptides that accumulate as amyloid deposits in a tissue-specific manner. FAF patients deposit both 8 and 5 kDa peptides d...

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Bibliographische Detailangaben
Hauptverfasser: Page, Lesley J, Suk, Ji Young, Huff, Mary E, Lim, Hee-Jong, Venable, John, Yates, John, Kelly, Jeffery W, Balch, William E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356312/
https://ncbi.nlm.nih.gov/pubmed/16281052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600872
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