Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Amyloid β-peptide (Aβ) is generated by the consecutive cuts of two membrane-bound proteases. β-Secretase cuts at the N terminus of the Aβ domain, whereas γ-secretase mediates the C-terminal cut. Recent evidence suggests that the presenilin (PS) proteins, PS1 and PS2, may be γ-secretases. Because PSs...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132277899 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|