Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Amyloid β-peptide (Aβ) is generated by the consecutive cuts of two membrane-bound proteases. β-Secretase cuts at the N terminus of the Aβ domain, whereas γ-secretase mediates the C-terminal cut. Recent evidence suggests that the presenilin (PS) proteins, PS1 and PS2, may be γ-secretases. Because PSs...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132277899 |
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