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Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Amyloid β-peptide (Aβ) is generated by the consecutive cuts of two membrane-bound proteases. β-Secretase cuts at the N terminus of the Aβ domain, whereas γ-secretase mediates the C-terminal cut. Recent evidence suggests that the presenilin (PS) proteins, PS1 and PS2, may be γ-secretases. Because PSs...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124353/ https://ncbi.nlm.nih.gov/pubmed/12048259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132277899 |
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