Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

Amyloid β-peptide (Aβ) is generated by the consecutive cuts of two membrane-bound proteases. β-Secretase cuts at the N terminus of the Aβ domain, whereas γ-secretase mediates the C-terminal cut. Recent evidence suggests that the presenilin (PS) proteins, PS1 and PS2, may be γ-secretases. Because PSs...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Edbauer, Dieter, Winkler, Edith, Haass, Christian, Steiner, Harald
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132277899
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