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All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade
The mechanism of pI258 arsenate reductase (ArsC) catalyzed arsenate reduction, involving its P-loop structural motif and three redox active cysteines, has been unraveled. All essential intermediates are visualized with x-ray crystallography, and NMR is used to map dynamic regions in a key disulfide...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124290/ https://ncbi.nlm.nih.gov/pubmed/12072565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132142799 |
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