Role of LAMP-2 in Lysosome Biogenesis and Autophagy

In LAMP-2–deficient mice autophagic vacuoles accumulate in many tissues, including liver, pancreas, muscle, and heart. Here we extend the phenotype analysis using cultured hepatocytes. In LAMP-2–deficient hepatocytes the half-life of both early and late autophagic vacuoles was prolonged as evaluated...

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Hauptverfasser: Eskelinen, Eeva-Liisa, Illert, Anna Lena, Tanaka, Yoshitaka, Schwarzmann, Günter, Blanz, Judith, von Figura, Kurt, Saftig, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124165/
https://ncbi.nlm.nih.gov/pubmed/12221139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-02-0114
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