Identification of Raf-1 S471 as a Novel Phosphorylation Site Critical for Raf-1 and B-Raf Kinase Activities and for MEK Binding

The Ras-Raf-MAPK cascade is a key growth-signaling pathway and its uncontrolled activation results in cell transformation. Although the general features of the signal transmission along the cascade are reasonably defined, the mechanisms underlying Raf activation remain incompletely understood. Here,...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhu, Jun, Balan, Vitaly, Bronisz, Agnieszka, Balan, Karina, Sun, Hengrui, Leicht, Deborah T., Luo, Zhijun, Qin, Jun, Avruch, Joseph, Tzivion, Guri
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Cell Biology 2005
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237079/
https://ncbi.nlm.nih.gov/pubmed/16093354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-02-0090
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