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Identification of Raf-1 S471 as a Novel Phosphorylation Site Critical for Raf-1 and B-Raf Kinase Activities and for MEK Binding

The Ras-Raf-MAPK cascade is a key growth-signaling pathway and its uncontrolled activation results in cell transformation. Although the general features of the signal transmission along the cascade are reasonably defined, the mechanisms underlying Raf activation remain incompletely understood. Here,...

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Main Authors: Zhu, Jun, Balan, Vitaly, Bronisz, Agnieszka, Balan, Karina, Sun, Hengrui, Leicht, Deborah T., Luo, Zhijun, Qin, Jun, Avruch, Joseph, Tzivion, Guri
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Cell Biology 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237079/
https://ncbi.nlm.nih.gov/pubmed/16093354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-02-0090
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