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MEK-1 Activates C-Raf Through a Ras-Independent Mechanism
C-Raf is a member of the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway that plays key roles in diverse physiological processes and is upregulated in many human cancers. C-Raf activation involves binding to Ras, increased phosphorylation and interactions with co-factors. H...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608709/ https://ncbi.nlm.nih.gov/pubmed/23360980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.01.015 |
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