MEK-1 Activates C-Raf Through a Ras-Independent Mechanism

C-Raf is a member of the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway that plays key roles in diverse physiological processes and is upregulated in many human cancers. C-Raf activation involves binding to Ras, increased phosphorylation and interactions with co-factors. H...

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Détails bibliographiques
Auteurs principaux: Leicht, Deborah T., Balan, Vitaly, Zhu, Jun, Kaplun, Alexander, Bronisz, Agnieszka, Rana, Ajay, Tzivion, Guri
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608709/
https://ncbi.nlm.nih.gov/pubmed/23360980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.01.015
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