ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence

Clp/Hsp100 ATPases comprise a large family of ATP-dependent chaperones, some of which are regulatory components of two-component proteases. Substrate specificity resides in the Clp protein and the current thinking is that Clp proteins recognize motifs located near one or the other end of the substra...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hoskins, Joel R., Yanagihara, Katsuhiko, Mizuuchi, Kiyoshi, Wickner, Sue
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177439/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.172378899
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