The protofilament structure of insulin amyloid fibrils

Under solution conditions where the native state is destabilized, the largely helical polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic cross-β structure. However, there is a lack of information relating the 4.8 Å β-strand repeat to the higher order assembl...

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Bibliografiska uppgifter
Huvudupphovsmän: Jiménez, José L., Nettleton, Ewan J., Bouchard, Mario, Robinson, Carol V., Dobson, Christopher M., Saibil, Helen R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC123117/
https://ncbi.nlm.nih.gov/pubmed/12093917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.142459399
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