The protofilament structure of insulin amyloid fibrils

Under solution conditions where the native state is destabilized, the largely helical polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic cross-β structure. However, there is a lack of information relating the 4.8 Å β-strand repeat to the higher order assembl...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Jiménez, José L., Nettleton, Ewan J., Bouchard, Mario, Robinson, Carol V., Dobson, Christopher M., Saibil, Helen R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2002
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123117/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12093917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.142459399
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