A glutamate residue at the C terminus regulates activity of inward rectifier K(+) channels: Implication for Andersen's syndrome
G protein-coupled inward rectifiers (GIRKs) are activated directly by G protein βγ subunits, whereas classical inward rectifiers (IRKs) are constitutively active. We found that a glutamate residue of GIRK2 (E315), located on a hydrophobic domain of the C terminus, is crucial for the channel activati...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2002
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122682899 |
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