A glutamate residue at the C terminus regulates activity of inward rectifier K(+) channels: Implication for Andersen's syndrome
G protein-coupled inward rectifiers (GIRKs) are activated directly by G protein βγ subunits, whereas classical inward rectifiers (IRKs) are constitutively active. We found that a glutamate residue of GIRK2 (E315), located on a hydrophobic domain of the C terminus, is crucial for the channel activati...
Αποθηκεύτηκε σε:
| Εκδόθηκε σε: | Proc Natl Acad Sci U S A |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2002
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122682899 |
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