A glutamate residue at the C terminus regulates activity of inward rectifier K(+) channels: Implication for Andersen's syndrome

G protein-coupled inward rectifiers (GIRKs) are activated directly by G protein βγ subunits, whereas classical inward rectifiers (IRKs) are constitutively active. We found that a glutamate residue of GIRK2 (E315), located on a hydrophobic domain of the C terminus, is crucial for the channel activati...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Lei, Kawano, Takeharu, Bajic, Sibinka, Kaziro, Yoshito, Itoh, Hiroshi, Art, Jonathan J., Nakajima, Yasuko, Nakajima, Shigehiro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.122682899
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